CALL FOR PAPERS Integrative and Translational Physiology: Inflammation, Immunity, and Organ System Physiology Attenuated thermoregulatory, metabolic, and liver acute phase protein response to heat stroke in TNF receptor knockout mice
نویسندگان
چکیده
Lisa R. Leon, Shauna Dineen, Michael D. Blaha, Maria Rodriguez-Fernandez, and David C. Clarke Thermal Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts; Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California; and Department of Biological Engineering and Center for Cellular Decision Processes, Massachusetts Institute of Technology, Cambridge, Massachusetts
منابع مشابه
1 2 3 4 Attenuated Thermoregulatory , Metabolic and Liver Acute Phase Protein Response to 5 Heat Stroke in TNF Receptor Knockout Mice
40 Tumor necrosis factor (TNF) is considered an adverse mediator of heat stroke (HS) based 41 on clinical studies showing high serum levels. However, soluble TNF receptors (sTNFR; TNF 42 antagonists) were higher in survivors than nonsurvivors and TNFR KO mice showed a trend 43 towards increased mortality suggesting TNF has protective actions for recovery. We delineated 44 TNF actions in HS by c...
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Biedenkapp JC, Leon LR. Increased cytokine and chemokine gene expression in the CNS of mice during heat stroke recovery. Am J Physiol Regul Integr Comp Physiol 305: R978–R986, 2013. First published September 11, 2013; doi:10.1152/ajpregu.00011.2013.— Heat stroke (HS) is characterized by a systemic inflammatory response syndrome (SIRS) consisting of profound core temperature (Tc) changes in mice...
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